MPC1 is down-regulated in lung cancer and associated with immune infiltration

Lung cancer is the highest mortality as well as prevalence of tumor-related diseases in the world, and there is no very effective way for early screening of lung cancer, so finding an accurate biomarker is necessary for early diagnosis of lung cancer. In this research, the MPC1 gene expression level in a variety of tumors was analyzed by bio-informatics analysis, and prognostic analysis was performed, focusing on lung cancer patients to check the diagnostic accuracy of ROC for MPC1, followed by KEGG and GO analysis to find out the biological processes that MPC1 may be involved in, and then immune infiltration analysis to further confirm some of the possible MPC1 functions, and finally, MPC1 related proteins were searched by SRTING protein interaction analysis. The analysis results revealed that MPC1 expression was downregulated in a variety of cancers, and in lung cancer, MPC1 expression was significantly down-regulated, and the significance reached p < 0.005, with a high diagnostic accuracy of AUC: 0.828 for ROC, and the expression level of MPC1 was significantly down-regulated in patients who were smokers, and was correlated with the age of cigarette smoking, age, and the degree of malignancy of the tumors. By immune infiltration analysis, it was found that in lung cancer, the expression of MPC1 was positively correlated with a variety of immune cells, among which, the strongest correlation was with Follicular helper T cell (TFH), R=0.291, followed by enosinophils, R=0.281, these results indicated that the low expression of MPC1 was probably related to the immune escape of the tumor Related. Finally, the nine proteins with the highest correlation with MPC1 were found to be related to inflammatory factors. These results suggest that MPC1 may be a new direction for tumor immunity, and restoring the body's tumor immunity by promoting the expression of MPC1 will make MPC1 a new marker for lung cancer and a new target for lung cancer treatment.