Emerging Advances in Transition Metal-Catalyzed C-H Bond Functionalizations Towards C-Glycosides

Abstract: This review summarizes the recent trends in the transition-metal-catalyzed C-H bond functionalization approach to access C-branched (hetero)aryl/alkenyl/alkyl glycosides with reaction characteristics and proposed mechanisms. Recently, the Transition-metal-catalyzed C-H functionalization has arisen as a groundbreaking and versatile method for producing potent C-branched glycosides feasibly and efficiently. Nowadays, site-selective functionalization of C-H bonds in carbohydrate chemistry is highly demanded, owing to the intricate and highly stable nature of C-H bonds. In this context, we systematically summarize the C-H glycosylation of arenes, C-H arylation of glycoside, and Cattelani-strategy with mechanistic investigation. Also, the applications of transition-metal-catalyzed C-glycosylation for the formation of biologically active molecules are discussed.