化学
先天免疫系统
Boosting（机器学习）
细胞毒性T细胞
免疫
T细胞
CD8型
细胞生物学
免疫学
免疫系统
生物化学
受体
体外
生物
人工智能
计算机科学
作者
Linying Dong,Xuqian Deng,Yan Li,Xiaolan Zhu,Mingbo Shu,Jingyi Chen,Huacheng Luo,Keli An,Ming Cheng,Penghui Zhang,Weihong Tan
摘要
The messenger RNA (mRNA) vaccines hold great significance in contagion prevention and cancer immunotherapy. However, safely and effectively harnessing innate immunity to stimulate robust and durable adaptive immune protection is crucial, yet challenging. In this study, we synthesized a library of stimuli-responsive bivalent ionizable lipids (srBiv iLPs) with smart molecular blocks responsive to esterase, H
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