Process Development

Process Development aims to bridge the gap between the laboratory synthesis of an organic compound and its industrial manufacture on a large scale. The text uses real examples to show the problems which may be encountered in scaling up chemical syntheses and the ways in which these problems may be overcome. The major part of the book is devoted to genuine case histories from ICI/Zeneca Pharmaceuticals. Through a range of carefully chosen examples, the book explains how it is possible to synthesize multi-kilogram quantities of a new organic compound which has previously been made in the laboratory only on the milligram scale. A range of aliphatic, aromatic, and heterocyclic compounds is covered.