微泡
冷冻干燥
化学
药物输送
色谱法
食品科学
化学工程
纳米技术
材料科学
生物化学
工程类
小RNA
基因
作者
Xiaohu Ge,Tianshi Li,Lu Lu,Chunle Han,Miao Wang,Huanqing Du,Ning Chen,Mengya Gao,Na Wang,Dongli Qi,Wei Bai,Jianxin Yin,Fengwei Dong
标识
DOI:10.1101/2023.10.16.562624
摘要
ABSTRACT Bovune milk exosomes (MK-exo) have bioactive effects on the health of consumers and can also serve as excellent drug delivery vehicles. However, long-term preservation and transportation remain major challenges at present. In this report, high-quality MK-exo are prepared on a large scale. We then developed a lyophilization method belonging to MK-exo, and performed acceleration and long-term stability experiments on the lyophilized MK-exo to evaluate the effect of lyophilization. The results showed that the lyophilized MK-exo can be stored at room temperature for at least 3 months and 2-8°C℃ for 15 months. These findings provide data support for further understanding of the properties and applications of MK-exo.
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