CRISPR/Cas12a-Powered Nanoconfined Biosensing Platform with Hybrid Chain Reaction Cascading Guanine Nanowire Amplification for Ultrasensitive Dual-Mode Detection of Lipopolysaccharide

Traditional endotoxin detection methods face challenges in sensitivity, interference resistance, and reliability. This study develops a CRISPR/Cas12a-powered nanoconfined biosensing system that integrates mesoporous nanoengineering with a hybrid chain reaction (HCR)...