Research Progress of Skeletal Muscle Injury Repair and Treatment Strategies

Skeletal muscle is the most abundant tissue in the human body.It has high adaptability and regenerative potential.Skeletal muscle injuries are very common in people's lives, often secondary to various acute and chronic injuries and diseases.There are three main stages in the repair and regeneration process: the destruction stage of the initial inflammatory response, the regeneration stage of muscle satellite cell (MSCs) activation and proliferation, and the remodeling stage of the maturation of regenerated muscle fibers, among which, muscle satellite cells reside in the body and are muscle stem cells required for skeletal muscle growth and repair of damaged muscle fibers.The repair process is controlled by complex and precise regulatory mechanisms, including the interaction of cells and cells, cells and matrix, and extracellular secretory factors.There are many clinical treatment options for skeletal muscle injury, including physical, drug, surgical therapy and various new therapies such as growth factor injection, muscle stem cell combined or without bio-scaffold transplantation, anti-fibrosis treatment, and medical ozone injection.This article reviews skeletal muscle regeneration mechanisms and repair methods, in order to help clinicians choose appropriate treatment methods, and promote the development and application of more effective treatment strategies.Skeletal muscle is one of the most abundant tissues in the human body, accounting for about 40% of the total body mass and consists of thousands of contractile bundles of muscle fibers.Each muscle fiber is a muscle cell and is covered and joined together by connective tissue.People's