视网膜
增殖性玻璃体视网膜病变
发病机制
视网膜静脉
医学
黄斑变性
视网膜病变
糖尿病性视网膜病变
炎症
免疫学
眼科
视网膜脱离
内分泌学
糖尿病
作者
Ruihan Xiao,Chunyan Lei,Yi Zhang,Meixia Zhang
标识
DOI:10.1016/j.exer.2023.109556
摘要
Interleukin-6 (IL-6) is a pleiotropic cytokine that participates in immunomodulation, inflammation, increases vascular permeability, hematopoiesis, and stimulates cell proliferation, among other biological processes. It exerts effects primarily through the classic and trans-signaling pathways. Many studies have demonstrated that IL-6 plays a critical role in the development of retinal diseases including diabetic retinopathy, uveitis, age-related macular degeneration, glaucoma, retinal vein occlusion, central serous chorioretinopathy and proliferative vitreoretinopathy. Thus, the progressive development of drugs targeting IL-6 and IL-6 receptor may play a role in the treatment of multiple retinal diseases. In this article, we comprehensively review the IL-6's biological functions of and its mechanisms in the pathogenesis of various retinal diseases. Furthermore, we summarize the drugs targeting IL-6 and its receptor and prospect their potential application in retinal diseases, hoping to provide new ideas for the treatment of retinal diseases.
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