An efficient, reusable, eco-friendly CoCl2/3-(2-aminoethyl)-1-methyl-1H-imidazol-3-ium bromide [Aemim]Br catalyzed solvent, palladium, copper, base free Sonogashira coupling reactions

An innovative, efficient CoCl2/3-(2-aminoethyl)-1-methyl-1H-imidazol-3-ium bromide [Aemim]Br was created and examined as an organo-catalyst for the Sonogashira coupling process at 70°C in the absence of a solvent. By using this approach, phenylacetylene was reacted with several aryl halides (Cl, Br, and I) in good to outstanding yields with high rate. This catalyst, which was free from copper, palladium, and phosphine, was stable in the reaction environment and could be employed again for at least seven times without noticeably losing catalytic activity.