Recent Advances in the Synthesis and Biological Activities of Quinolactacin and Its Derivatives: A Comprehensive Review

Abstract: In recent years, quinolactacins and their derivatives have attracted significant research attention due to their distinctive structural features and intriguing biological properties. These heterocyclic compounds have emerged as promising candidates in medicinal chemistry due to their broad spectrum of therapeutic activities. This review article provides a comprehensive study on recent progress in synthesising and investigating the biological properties of quinolactacins and their diverse analogues, offering insights into the diverse synthetic strategies that have been explored to enhance the efficiency and scalability of their production. The primary emphasis lies on the biological activities exhibited by quinolactacins, including their notable anti-bacterial efficacies, anti-cancer, anti-proliferative, anti-oxidant, anti-malarial, and anti-viral. These compounds have shown great potential as therapeutic agents in the fight against various infectious diseases and cancers, making them promising candidates for drug development. Moreover, this study sheds light on the latest endeavours aimed for the synthesis of quinolactacins and their derivatives. This study serves as a valuable resource for researchers who aim to investigate and further harness the therapeutic potential of quinolactacins and their derivatives in the battle against life-threatening diseases, paving the way for future breakthroughs in drug development.