癌症研究
生物
组蛋白脱乙酰基酶
靶向治疗
基因敲除
脂肪生成
脂质代谢
癌症
组蛋白
细胞培养
生物化学
基因
遗传学
作者
Qi Wang,Daojia Miao,Ruijie Liu,Mingfeng Li,Zirui Dong,Yuenan Liu,Chao Yang,Hongmei Yang,Keshan Wang,Zhiyong Xiong,Xiaoping Zhang
标识
DOI:10.1016/j.jare.2025.08.007
摘要
Our findings reveal that KAT2B suppresses de novo lipogenesis by interfering with HDAC5-LSD1 complex assembly, and highlight the potential of FASN inhibitors as a therapeutic strategy for RCC patients with low KAT2B expression.
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