Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes

Brief Summary: This study used three high-throughput single-cell technologies to generate a pancreatic islet cell atlas from 24 organ donors with type 1 diabetes (T1D), autoantibody positive and healthy donors. The most remarkable finding was that a subset of exocrine ductal cells appears to acquire a signature of tolerogenic dendritic cells in an attempt at immune suppression in donors with T1D.