化学
废止
过渡金属
催化作用
喹啉
炔基化
烷基化
碳纤维
酰化
组合化学
有机化学
路易斯酸
合成子
螯合作用
复合材料
复合数
材料科学
作者
Shubhajit Basak,Tripti Paul,Santu Mandal,Pallab Karjee,Maniya Vadakanamala Nanjegowda,Tharmalingam Punniyamurthy
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:2023-03-20
卷期号:55 (21): 3454-3469
被引量:2
摘要
Abstract C8-Substituted quinoline (QN) and 1,2,3,4-tetrahydroquinoline (THQ) scaffolds are featured in numerous bioactive compounds and natural products. Appreciable efforts have been made towards the development of elegant techniques to functionalize the C8–H bond of QNs and THQs. The transition-metal-catalyzed chelation-assisted C–H activation strategy has emerged as an effective synthetic tool among existing methods. This review focuses on recent advances in transition-metal-catalyzed directed carbon–carbon bond forming reactions for the C8–H functionalization of QNs and THQs (till February 2023). The discussion has been categorized based on the type of reaction. 1 Introduction 2 Acylation 3 Alkylation 4 Alkenylation 5 Alkynylation 6 Allylation 7 Annulation 8 Arylation 9 Conclusion and Outlook
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