Construction of alkynyl and acyl disulfides directly through thiol-modification withN-alkynylthio phthalimides under acid catalysis

Acid-catalyzed disulfuration and rearrangement have been disclosed for the construction of alkynyl or acyl disulfides from thiols and N -alkynylthio phthalimides, enabling access to disulfide-modified thiodrugs, thiopeptides and thioglycosides.