癌症
医学
临床试验
维生素C
不利影响
癌细胞
维生素
癌症研究
信号转导
癌症治疗
生物信息学
肿瘤科
药理学
内科学
生物
生物化学
作者
Dianfa Fan,Xiyu Liu,Zhen Shen,Pan Wu,Liping Zhong,Faquan Lin
标识
DOI:10.1016/j.biopha.2023.114695
摘要
Vitamin C, a small organic molecule, is widely found in fruits and vegetables and is an essential nutrient in the human body. Vitamin C is closely associated with some human diseases such as cancer. Many studies have shown that high doses of vitamin C have anti-tumor ability and can target tumor cells in multiple targets. This review will describe vitamin C absorption and its function in cancer treatment. We will review the cellular signaling pathways associated with vitamin C against tumors depending on the different anti-cancer mechanisms. Based on this, we will further describe some applications of the use of vitamin C for cancer treatment in preclinical and clinical trials and the possible adverse events that can occur. Finally, this review also assesses the prospective advantages of vitamin C in oncology treatment and clinical applications.
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