生物利用度
镉
化学
体内
体外
食品科学
吸收(声学)
体外毒理学
药理学
色谱法
环境化学
生物化学
生物
生物技术
有机化学
物理
声学
作者
Yanyan Wei,Xiaoman Zheng,Zengyu Zhang,Huanting Liang,Min Gu,Fangke Shen,M. J. I. Shohag,Xiaofeng Li
标识
DOI:10.1021/acs.jafc.1c03284
摘要
The correlation of in vitro and in vivo assays for determining bioavailable Cd amounts in vegetables is limited. Herein, the correlations between Cd relative bioavailability (Cd-RBA) in rat models and Cd bioaccessibility in four in vitro assays were examined in vegetables. Results showed that the combined liver plus kidney data provided the appropriate endpoint and was used as a biomarker to estimate Cd-RBA. The Cd-RBA was negatively correlated with the mole ratio of Ca/Cd and Fe/Cd in vegetables. Strong in vivo-in vitro correlations were found from physiologically based extraction test (PBET) and in vitro gastrointestinal (IVG) (R2 = 0.66-0.69). We concluded that PBET and IVG were optimal models for Cd-RBA determination in vegetables. The nutritional elements in the vegetables could affect Cd absorption. Furthermore, the Cd bioavailability in vegetables should be considered because risk estimates solely based on the total Cd concentration in vegetables would overestimate Cd intake.
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