斑马鱼
化学
药理学
氧化应激
内分泌学
抗氧化剂
生物化学
内科学
毒性
谷胱甘肽
谷胱甘肽过氧化物酶
生物
作者
Tomasz Antonowski,Karol Wiśniewski,Piotr Podlasz,Adam Osowski,Joanna Wojtkiewicz
出处
期刊:Nutrients
[MDPI AG]
日期:2021-09-24
卷期号:13 (10): 3346-
摘要
Inositol is a natural substance found widely in plants. It is used in therapies for many medical cases. The aim of this study was to determine the toxicity of myo-inositol (MI) and to investigate its potential hepatoprotective character. In the first part of the study, zebrafish embryos were incubated with 5, 10, 20, 40, 60, 80, and 100 mg/mL MI. Endpoints such as survivability, hatching rate, malformation, and mobility were evaluated. Our results demonstrated that the high doses of MI lead to increased mortality and malformations and reduce the hatching rate in comparison to the control group. Moreover, low doses of this compound do not produce a negative effect on zebrafish and even have the ability to increase the hatching rate and mobility. In the second part of the study, the hepatoprotective effect of MI was tested. Zebrafish larvae from the line Tg (fabp10a:DsRed) were incubated for 24 h with 1% and 2% ethanol (EtOH), 5 mg/mL of MI with 1% EtOH, and 5 mg/mL of MI with 2% EtOH. No significant differences between the groups with EtOH and the group treated with EtOH with MI were observed. Our results suggest that MI has no positive benefits on hepatocytes of zebrafish larvae.
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