光热治疗
聚集诱导发射
荧光
生物相容性
纳米颗粒
化学
量子产额
纳米技术
近红外光谱
材料科学
生物医学中的光声成像
光电子学
光学
物理
冶金
作者
Dingyuan Yan,Wei Xie,Jianyu Zhang,Lei Wang,Dong Wang,Ben Zhong Tang
标识
DOI:10.1002/anie.202111767
摘要
Owing to their versatile functionality and tunable energy dissipation, aggregation-induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE-active phototheranostic agents in the second near-infrared window (NIR-II, 1000-1700 nm), which allows superior resolution and minimized photodamage, is still a formidable challenge. Herein, benzo[c]thiophene serves as an electron-rich and bulky donor (D)/π-bridge, which can enlarge the conjugation length and distort the backbone of an AIEgen. By precise D/π-bridge engineering, highly stable NIR-II AIEgen DPBTA-DPTQ nanoparticles are obtained with acceptable NIR-II fluorescence quantum yield and excellent photothermal conversion efficiency. In addition, the spatial conformation of DPBTA-DPTQ is determined for the first time by X-ray single crystal diffraction and theoretical simulations. DPBTA-DPTQ NPs have good biocompatibility and show efficient photothermal therapeutic effects in in vitro tests. Furthermore, DPBTA-DPTQ NPs were used in fluorescence-photoacoustic-photothermal trimodal imaging-guided photothermal eradication of tumors in HepG2 and B16-F10 tumor-xenografted mice.
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