荧光团
紧身衣
荧光
检出限
量子产额
化学
生物相容性
光化学
色谱法
有机化学
光学
物理
作者
Yifeng Wang,Chenggong Ma,Xuwei Zheng,Minzi Ju,Yongqian Fu,Xing Zhang,Baolong Shen
标识
DOI:10.1016/j.jphotochem.2021.113516
摘要
In this work, a BODIPY-based multi-site red emission fluorescent probe MRS-BOD for the detection of carboxylesterase 1 (CES1) was designed and synthesized. MRS-BOD showed good biocompatibility and could be used to monitor the activity of CES1 in living cells. MRS-BOD emission is located in the red emission region, which has the advantages of less background interference and less damage to biological samples. MRS-BOD has multiple CES1 recognition sites, and the ultra-sensitive quantification of CES1 has been successfully achieved. The low detection limit of MRS-BOD was calculated as 2.5 ng/mL, and the fluorescence quantum yield was calculated as 0.49. This study can promote the development of CES1 fluorescent probes and help the identification of related diseases.
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