Multicharged Supramolecular Assembly Mediated by Polycationic Cyclodextrin for Efficiently Photodynamic Antibacteria

Supramolecular antimicrobial materials based on synthetic macrocycles have recently aroused enormous interests due to their controllable and effective antibacterial treatment. Herein, a multicharged supramolecular assembly was fabricated employing the moderate host-guest interaction between hexa-adamantane-appended ruthenium polypyridyl (Ru2) and polycationic cyclodextrin (CD-QAS) in water. The positively multicharged feature of supramolecular assembly could remarkably enhance the specific intercalation and accumulation in negatively charged bacteria membrane leading to the physical membrane damage. Subsequently, the assembly could efficiently initiate the significant generation of singlet oxygen (1O2) in situ when irradiated with white light thus exhibiting a highly efficient antibacterial capability. Significantly, antibacterial experiments indicated that Ru2/CD-QAS displayed less effect on suppressing the growth of E. coli only about 25% in the absence of light while they exhibited excellent killing efficiency more than 99% toward E. coli under light irradiation. This work provides a simple approach for constructing supramolecular antimicrobial materials for synergistic photodynamic antibacteria.