马尔科夫尼科夫法则
化学
对映选择合成
烯醇
催化作用
烯烃纤维
组合化学
钯
氢化物
有机化学
区域选择性
氢
作者
Alexander Schuppe,James Levi Knippel,Gustavo M. Borrajo‐Calleja,Stephen L. Buchwald
摘要
The catalytic enantioselective synthesis of α-chiral olefins represents a valuable strategy for rapid generation of structural diversity in divergent syntheses of complex targets. Herein, we report a protocol for the dual CuH- and Pd-catalyzed asymmetric Markovnikov hydroalkenylation of vinyl arenes and the anti-Markovnikov hydroalkenylation of unactivated olefins, in which readily available enol triflates can be utilized as alkenyl coupling partners. This method allowed for the synthesis of diverse α-chiral olefins, including tri- and tetrasubstituted olefin products, which are challenging to prepare by existing approaches.
科研通智能强力驱动
Strongly Powered by AbleSci AI