纳米载体
药物输送
药品
纳米技术
纳米医学
靶向给药
跨细胞
纳米颗粒
化学
材料科学
药理学
医学
生物化学
作者
Mohammad Souri,M. Soltani,Farshad Moradi Kashkooli,Mohammad Kiani Shahvandi
标识
DOI:10.1016/j.jconrel.2021.11.024
摘要
Nanocarriers have been widely employed in preclinical studies and clinical trials for the delivery of anticancer drugs. The most important causes of failure in clinical translation of nanocarriers is their inefficient accumulation and penetration which arises from special characteristics of tumor microenvironment such as insufficient blood supply, dense extracellular matrix, and elevated interstitial fluid pressure. Various strategies such as engineering extracellular matrix, optimizing the physicochemical properties of nanocarriers have been proposed to increase the depth of tumor penetration; however, these strategies have not been very successful so far. Novel strategies such as transformable nanocarriers, transcellular transport of peptide-modified nanocarriers, and bio-inspired carriers have recently been emerged as an advanced generation of drug carriers. In this study, the latest developments of nanocarrier-based drug delivery to solid tumor are presented with their possible limitations. Then, the prospects of advanced drug delivery systems are discussed in detail.
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