蜕膜化
子宫内膜
蜕膜细胞
间质细胞
医学
怀孕
反复流产
生物
流产
细胞生物学
佩里
男科
蜕膜
产科
妊娠期
内分泌学
癌症研究
胎盘
胎儿
遗传学
作者
Emma S. Lucas,Pavle Vrljicak,Joanne Muter,Maria Diniz-da-Costa,Paul J. Brighton,Chow-Seng Kong,Julia Lipecki,Katherine Fishwick,Joshua Odendaal,Lauren J. Ewington,Siobhan Quenby,Sascha Ott,Jan J. Brosens
标识
DOI:10.1038/s42003-020-0763-1
摘要
Abstract During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC). Perturbations in this process, termed decidualization, leads to breakdown of the feto-maternal interface and miscarriage, but the underlying mechanisms are poorly understood. Here, we reconstructed the decidual pathway at single-cell level in vitro and demonstrate that stromal cells first mount an acute stress response before emerging as DC or senescent DC (snDC). In the absence of immune cell-mediated clearance of snDC, secondary senescence transforms DC into progesterone-resistant cells that abundantly express extracellular matrix remodelling factors. Additional single-cell analysis of midluteal endometrium identified DIO2 and SCARA5 as marker genes of a diverging decidual response in vivo. Finally, we report a conspicuous link between a pro-senescent decidual response in peri-implantation endometrium and recurrent pregnancy loss, suggesting that pre-pregnancy screening and intervention may reduce the burden of miscarriage.
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