海绵
链霉菌
立体化学
绝对构型
拉伤
化学
生物
植物
细菌
古生物学
解剖
作者
Siqiang Chen,Qingbo Zhang,Xinya Zhang,Xiaodong Jiang,Haibo Zhang,Yiguang Zhu,Changsheng Zhang,Liping Zhang
标识
DOI:10.1080/14786419.2020.1867131
摘要
A new cyclo-heptadepsipeptide xanthostatin B (1), together with isobutyryl hexapeptide (2), xanthostatin (3), TXS-1 (4) and TXS-2 (5), were isolated from the marine sponge derived Streptomyces sp. SCSIO 40064. The structures were elucidated by comprehensive spectroscopic data analyses and comparison with the literatures. The D-Val unit in 1 was assigned by Marfey’s method. The absolute configuration of 4 was determined by X-ray crystallographic analysis. Compounds 1‒5 were evaluated for the inhibitory activities against four pharmaceutical targets and six antibacterial indicator strains. Compound 5 displayed α-glucosidase inhibitory activity with IC50 value of 18.67 ± 1.27 µM.
科研通智能强力驱动
Strongly Powered by AbleSci AI