Successful treatment of depression with psychotic features using accelerated intermittent theta burst stimulation

• Repetitive Transcranial Magnetic Stimulation (rTMS) has not been studied extensively in depressed patients with severe symptom burden and psychosis. • Intermittent theta burst stimulation (iTBS) has comparable efficacy to standard rTMS in treating treatment resistant depression (TRD). • Novel high dose accelerated iTBS (aiTBS) protocols have demonstrated marked benefits in patients with treatment-resistant depression (TRD) and severe symptom burden. • aiTBS treatment algorithms may lead to rapid clinical improvement in patients with severe symptom burden and further randomized controlled trials are warranted.