邻苯二甲酸盐
尿
医学
体质指数
生理学
内分泌学
内科学
怀孕
化学
生物
遗传学
有机化学
作者
Dong Hoon Lee,Youn Hee Lim,Choong Ho Shin,Young Ah Lee,Bung Nyun Kim,Johanna Inhyang Kim,Yun Chul Hong
标识
DOI:10.1016/j.envres.2019.109020
摘要
Phthalate is a well-known endocrine-disrupting chemical that has anti-androgenic effects. Although there are several studies on the relationship between body composition and phthalate, studies that investigated the effects of phthalate on skeletal muscle during childhood are lacking. We analyzed data from 481 mother-and-child pairs enrolled in the Environment and Development of Children cohort in South Korea. We examined the association between phthalate metabolites (mono [2-ethyl-5-hydroxyhexyl] phthalate [MEHHP], mono [2-ethyl-5-oxohexyl] phthalate [MEOHP], molar sum of MEHHP and MEOHP [Σ DEHP], and mono-n-butyl phthalate [MnBP]) in prenatal maternal urine and children's urine at the age of 6, and body composition indices (body mass index [BMI] z-score, percentage of fat mass, fat mass index, percentage of skeletal muscle, and the skeletal muscle index [SMI]) measured when the child was 6 years using a bioelectrical impedance analyzer. A 2-fold increase in Σ DEHP and MnBP in the prenatal maternal urine was significantly associated with a −0.07 unit (95% CI: −0.11, −0.03) and −0.09 unit (95% CI: −0.14, −0.03) change in SMI, respectively, in 6-year old girls alone. BMI z-score was also negatively associated with a 2-fold increase in MEHHP and MnBP in prenatal maternal urine as −0.11 unit (95% CI: −0.22, −0.01) and −0.15 unit (95% CI: −0.28, −0.02) change, respectively, only among girls. Among boys, phthalate metabolites in the prenatal and children's urine were not significantly associated with any body composition indices. Our longitudinal study shows that high levels of prenatal exposure to phthalates are significantly associated with decreased SMI among girls. We can postulate that anti-androgenic effects of phthalates during pregnancy may affect girl offspring's muscle growth.
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