小胶质细胞
遗忘
神经科学
神经发生
突触
细胞生物学
英语
生物
吞噬作用
心理学
免疫学
认知心理学
炎症
作者
Chao Wang,Huimin Yue,Chunling Zhu,Yuwen Shen,Jiao Ma,Jie Li,Xiaodong Wang,Liang Wang,Binggui Sun,Peng Shi,Lang Wang,Yan Gu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-02-07
卷期号:367 (6478): 688-694
被引量:366
标识
DOI:10.1126/science.aaz2288
摘要
Synapses between engram cells are believed to be substrates for memory storage, and the weakening or loss of these synapses leads to the forgetting of related memories. We found engulfment of synaptic components by microglia in the hippocampi of healthy adult mice. Depletion of microglia or inhibition of microglial phagocytosis prevented forgetting and the dissociation of engram cells. By introducing CD55 to inhibit complement pathways, specifically in engram cells, we further demonstrated that microglia regulated forgetting in a complement- and activity-dependent manner. Additionally, microglia were involved in both neurogenesis-related and neurogenesis-unrelated memory degradation. Together, our findings revealed complement-dependent synapse elimination by microglia as a mechanism underlying the forgetting of remote memories.
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