The advancements in information technology have enabled the supply chain members to share real-time information, which further facilitates the integration of supply chain members. Since supply chain integration is a prerequisite in achieving superior supply chain performance, the objective of the current study is to determine the relationship between IT-enabled supply chain management (e-supply chain management), supply chain integration, information sharing and the performance of supply chain as a whole. Also, many authors are of the view that e-SCM and information sharing can positively enhance the integration among supply chain members, thus, another objective is to determine whether supply chain integration mediates the relationship between e-SCM and supply chain performance or not. Similar relationship is tested with information sharing as a mediator. For this, samples of 293 respondents are taken from the pharmaceutical manufacturing units and pharmacies in India. Structural equation modelling is applied to test these relationships.