Photoacoustic Imaging Guided Photothermal and Chemodynamic Combined Therapy for Cancer Using "All in One" W18O49 Nanorod Agent

Chemodynamic therapy based on Fenton or Fenton-like reactions is an emerging cancer therapy that has attracted considerable attention due to its high selectivity for tumors. However, the low catalytic efficiency of the Fenton or Fenton-like agent limits its therapeutic effect. Combination therapies based on chemodynamic therapy using "all-in-one" agents show great potential for cancer treatment. In this study, W 18 O 49 nanorods with strong near-infrared absorption and excellent Fenton-like reaction performance were prepared, and their application in photoacoustic imaging-guided photothermal-chemodynamic combination cancer therapy was explored. First, hydrophobic W 18 O 49 nanorods were synthesized via a one-step pyrolysis method. Hydrophilic W 18 O 49 nanorods were then prepared via hydrophobic self-assembly between oleyl amine-coated W 18 O 49 nanorods and an amphiphilic polymer. The W 18 O 49 nanorods exhibited good photoacoustic, photothermal, and chemodynamic performance in vitro along with good photoacoustic imaging contrast and excellent therapeutic effect in photothermal-chemodynamic combination cancer therapy in vivo . This study provides a low-cost and easy-to-prepare agent for photothermal-chemodynamic combination therapy and promotes the application of photothermal-chemodynamic combination therapy in cancer treatment.