粒体自噬
尼氏体
海马体
自噬
神经科学
社会失败
海马结构
心理学
生物
染色
细胞凋亡
遗传学
生物化学
作者
Lanmin Guo,Ziyi Jiang,Run‐Cang Sun,Wei Wei Pang,Xiao Zhou,Meiling Du,Meng-Xiang Chen,Xinyue Lv,Jingtao Wang
标识
DOI:10.1016/j.brainresbull.2022.01.009
摘要
The social defeat stress model is commonly used to study depression and anxiety disorder, which can significantly affect the structure and function of neurons in the hippocampus; however, the relevant mechanism in neuronal loss has not been clearly defined. In the present study, a social defeat stress model was established in mice to evaluate the impact of social defeat stress on the structure of neurons in the hippocampus using Western blotting, immunofluorescence, Nissl staining, Golgi staining and transmission electron microscopy. The results demonstrated that social defeat stress leads to disruption of homeostasis in the hippocampus and the integrity of mitochondria in hippocampal neurons was markedly affected by enhanced mitophagy and autophagy resulting in inhibition of development and growth. These findings provide new insights into the mechanisms of neuronal development and growth due to social defeat stress, which should help in the development of new strategies to combat the effects of depression and anxiety disorder.
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