Advances in microfluidic analysis of residual antibiotics in food

Antibiotics residue in food is a big threat to human being health and life. Development of simple and fast detection techniques targeting residual antibiotics are urgently needed for food safety. Many analytical techniques have been used for the detection of antibiotic residues in food. Among these analytical techniques, microfluidic analysis gains increasing attention due to its advantages of low-cost, easy to carry, high integration, simple operation, and fast detection. In this review, we summarized the microfluidic devices applied in the analysis of antibiotic residues in food, mainly focusing on their detection techniques (including fluorescence, chemiluminescence, surface enhanced Raman spectroscopy, colorimetric method, electrochemical technique, and mass spectrometry), molecular recognition materials (such as antibodies, aptamers and molecularly imprinted polymers) and fabrication materials. Prospects and challenges of the microfluidic analysis platforms for practical applications were discussed in this review.