透明质酸
自愈水凝胶
CD44细胞
细胞外基质
纳米技术
糖胺聚糖
组织工程
化学
材料科学
生物医学工程
医学
生物化学
高分子化学
体外
解剖
作者
Aqeela Yasin,Ying Ren,Jingan Li,Yulong Sheng,Chang Cao,Kun Zhang
标识
DOI:10.3389/fbioe.2022.910290
摘要
Hyaluronic acid (HA) is a large non-sulfated glycosaminoglycan that is the main component of the extracellular matrix (ECM). Because of its strong and diversified functions applied in broad fields, HA has been widely studied and reported previously. The molecular properties of HA and its derivatives, including a wide range of molecular weights but distinct effects on cells, moisture retention and anti-aging, and CD44 targeting, promised its role as a popular participant in tissue engineering, wound healing, cancer treatment, ophthalmology, and cosmetics. In recent years, HA and its derivatives have played an increasingly important role in the aforementioned biomedical fields in the formulation of coatings, nanoparticles, and hydrogels. This article highlights recent efforts in converting HA to smart formulation, such as multifunctional coatings, targeted nanoparticles, or injectable hydrogels, which are used in advanced biomedical application.
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