Non‐covalent Sugar Modification and Self‐assembly of Fluorous Gold Nanoparticles Driven by Fluorous Interaction

Abstract Fluorous gold nanoparticle ( Fluo‐NP ), i.e. gold nanoparticle covered by fluorous ponytail (C 8 F 17 ‐) was prepared and found to self‐assemble into supra‐structures covered by carbohydrates (named supraF‐NP ), due to the strong fluorous interaction. More importantly, the re‐dispersed supraF‐NP (diameter around 200 nm) in water provided an alternative strategy to detect carbohydrate‐protein interaction in solution by naked eye.