Cookie Theft Picture Description: Linguistic and Neural Correlates

Event Abstract Back to Event Cookie Theft Picture Description: Linguistic and Neural Correlates Lynsey M. Keator1*, Shannon M. Sheppard1, Andreia V. Faria2, Kevin Kim1, Sadhvi Saxena1, Amy Wright1 and Argye E. Hillis1, 2, 3, 4 1 Johns Hopkins Medicine, Neurology, United States 2 Johns Hopkins University, The Russell H Morgan Department of Radiology and Radiological Science, United States 3 Johns Hopkins Medicine, Department of Physical Medicine and Rehabilitation, United States 4 Johns Hopkins University, Department of Cognitive Science, United States Problem/Hypothesis: Expressive language deficits, such as word finding, are common following a stroke and inhibit effective communication, as well as quality of life. Clinically, there is a paucity of sensitive and efficient tools for acute bedside administration to determine aphasia severity. We hypothesized that performance on a picture description task correlates with confrontational naming and analysis of this description contributes valuable information about lesion size, location, and percent damage to specific areas of the brain. Procedures/Analyses: 60 left hemisphere (LH) ischemic stroke patients aged 28-87 years (M=58.42; SD=13.24) were included (19 (32%) women; mean education=13.74±2.54). This cohort was tested acutely (48 hours following stroke) and a subset of participants (n=17) were tested chronically (6-12 months post stroke) with the Boston Naming Test, short form (BNT; Mack et al., 1992) and Cookie Theft Picture Description (BDAE; Goodglass & Kaplan, 1972). Cookie Theft Picture Descriptions were scored for number of words, syllables, correct content units (CU), syllables/content units (syll/CU) and ratio of left/right content units (L:R Ratio). Results were compared with published norms and standardized scoring for the Cookie Theft Picture Description (Yorkston & Beukelman, 1980; Agis et al., 2016) and BNT (Williams et al., 1989). Imaging: All participants received an acute MRI scan, including diffusion weighted-imaging. Acute ischemia was traced on DWI scans. A radiologist identified percent damage to cortical lobes, thalamus, basal ganglia, and each vascular territory on DWI, after co-registration to the respective anatomical atlas (divided by lobes, and nuclei, or vascular territories). Results: Acutely, mean scores were: BNT =19.38 ±10.07 (of 30; normal=27.5±2.4); cookie theft total CU = 6.82±4.36 (mean for controls=16.0±3.7), syll/CU M=11.55±18.02 (mean for controls=6.2±1.9), L:R Ratio M=.911±.691. Chronically, mean scores were: BNT M=24.17±4.58; cookie theft total CU M=11.12±4.9; syllables/CU M=6.74±3.32, L:R Ratio M=1.319±.639, indicating participants improved in naming, content, and efficiency of narrative speech. BNT scores correlated positively with total CU (r=.65, p<.05) and negatively with syll/CU (r=-.34, p<.05). Chronically, BNT scores correlated with CUs (r=.58, p<.05), but not syll/CU; however, this may reflect inadequate power to detect association at follow up (n=17). As hypothesized, total CU negatively correlated with percent damage to total LH (r=-0.38, p<.05), and percent damage across language areas; LH frontal (r=-.2970, p<.05), parietal (r=-.30, p<.05), and temporal (r=-.38, p<.05). Percent damage to LH MCA and PCA territories negatively correlated with total CU (r=-.43, p<.05 and r=-.27, p<.05, respectively). Final Conclusions: The Cookie Theft Picture Description which requires only two minutes to administer at bedside, captures an overall aphasia severity measure that correlates with percent damage to language cortex in acute stroke. This is important because other batteries are cumbersome at bedside. This analysis provides an efficient acute stroke assessment and measurement of change over time. Future studies will examine a larger cohort of participants longitudinally to determine additional neural correlates that predict language recovery. Acknowledgements This work was made possible by NIH grants ROI DC 011317 from NIDCD. We gratefully acknowledge this support. References Agis, D., Goggins, M. B., Oishi, K., Davis, C., Wright, A., & Hillis, A. E. (2016). Picturing the size and site of stroke with an expanded National Institutes of Health Stroke Scale. Stroke, 47(6), 1459-1465. Goodglass, H., Kaplan, E., Barresi, B.. Boston Diagnostic Aphasia Examination-Third Edition (BDAE-3) San Antonio: Pearson; 2000. Mack, W.J., Freed, D.M., Williams, B.W., & Henderson, V.W. (1992). Boston naming test: Shortened versions for use in Alzheimer’s disease. Journal of Gerontology, 47, 154-158. Yorkston, K. M., & Beukelman, D. R. (1980). An analysis of connected speech samples of aphasic and normal speakers. Journal of speech and hearing disorders, 45(1), 27-36. doi: 10.1044/jshd.4501.27. Keywords: Neuroimaging, Stroke, Aphasia, assessment, Language Conference: Academy of Aphasia 56th Annual Meeting, Montreal, Canada, 21 Oct - 23 Oct, 2018. Presentation Type: poster presentation Topic: not eligible for a student prize Citation: Keator LM, Sheppard SM, Faria AV, Kim K, Saxena S, Wright A and Hillis AE (2019). Cookie Theft Picture Description: Linguistic and Neural Correlates. Conference Abstract: Academy of Aphasia 56th Annual Meeting. doi: 10.3389/conf.fnhum.2018.228.00097 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Apr 2018; Published Online: 22 Jan 2019. * Correspondence: Ms. Lynsey M Keator, Johns Hopkins Medicine, Neurology, Baltimore, Maryland, 21287, United States, lkeator@jhmi.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Lynsey M Keator Shannon M Sheppard Andreia V Faria Kevin Kim Sadhvi Saxena Amy Wright Argye E Hillis Google Lynsey M Keator Shannon M Sheppard Andreia V Faria Kevin Kim Sadhvi Saxena Amy Wright Argye E Hillis Google Scholar Lynsey M Keator Shannon M Sheppard Andreia V Faria Kevin Kim Sadhvi Saxena Amy Wright Argye E Hillis PubMed Lynsey M Keator Shannon M Sheppard Andreia V Faria Kevin Kim Sadhvi Saxena Amy Wright Argye E Hillis Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.