A Grignard-Type Phase-Vanishing Method: Generation of Organomagnesium Reagent and Its Subsequent Addition to Carbonyl Compounds

A quadraphasic phase-vanishing system comprised of diethyl ether, magnesium, perfluoropolyether, and iodoalkane efficiently generated the corresponding Grignard reagents, which subsequently added to carbonyl compounds in the ether layer to afford alkylated alcohols in good yields.