蛋白质稳态
病态的
神经炎症
抄写(语言学)
生物
神经科学
转录因子
神经退行性变
医学
疾病
生物信息学
基因
细胞生物学
遗传学
炎症
免疫学
病理
哲学
语言学
作者
Wei Jin,Talal Jamil Qazi,Zhenzhen Quan,Nuomin Li,Hong Qing
标识
DOI:10.1177/1073858418811787
摘要
Neurodegenerative diseases (NDs) are considered heterogeneous disorders characterized by progressive pathological changes in neuronal systems. Transcription factors are protein molecules that are important in regulating the expression of genes. Although the clinical manifestations of NDs vary, the pathological processes appear similar with regard to neuroinflammation, oxidative stress, and proteostasis, to which, as numerous studies have discovered, transcription factors are closely linked. In this review, we summarized and reviewed the roles of transcription factors in NDs, and then we elucidated their functions during pathological processes, and finally we discussed their therapeutic values in NDs.
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