骨髓生成
IRF8
生物
斑马鱼
祖细胞
细胞生物学
细胞命运测定
转录因子
干扰素调节因子
髓样
祖细胞
免疫学
干细胞
遗传学
基因
作者
Luxiang Wang,Shuo Gao,Haihong Wang,Chang Xue,Xiaohui Liu,Hao Yuan,Zixuan Wang,Sai‐Juan Chen,Zhu Chen,Hugues de Thé,Yiyue Zhang,Wenqing Zhang,Jun Zhu,Jun Zhou
出处
期刊:Haematologica
[Ferrata Storti Foundation]
日期:2019-05-23
卷期号:105 (2): 325-337
被引量:9
标识
DOI:10.3324/haematol.2019.217596
摘要
Aproper choice of neutrophil-macrophage progenitor cell fate is essential for the generation of adequate myeloid subpopulations during embryonic development and in adulthood. The network governing neutrophil-macrophage progenitor cell fate has several key determinants, such as myeloid master regulators CCAAT enhancer binding protein alpha (C/EBPα) and spleen focus forming virus proviral integration oncogene (PU.1). Nevertheless, more regulators remain to be identified and characterized. To ensure balanced commitment of neutrophil-macrophage progenitors toward each lineage, the interplay among these determinants is not only synergistic, but also antagonistic. Depletion of interferon regulatory factor 2 binding protein 2b (Irf2bp2b), a well-known negative transcription regulator, results in a bias in neutrophil-macrophage progenitor cell fate in favor of macrophages at the expense of neutrophils during the stage of definitive myelopoiesis in zebrafish embryos. Mechanistic studies indicate that Irf2bp2b acts as a downstream target of C/EBPα, repressing PU.1 expression, and that SUMOylation confers the repressive function of Irf2bp2b. Thus, Irf2bp2b is a novel determinant in the choice of fate of neutrophil-macrophage progenitor cells.
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