Immunophenotypic dysplasia and aberrant T-cell antigen expression in acute myeloid leukaemia with complex karyotype and TP53 mutations

AIMS: mutations (AML-TP53) compared with AML with normal karyotype (AML-NK). METHODS: , were compared with 83 cases of AML-NK using FCI. RESULTS: Our findings demonstrated brighter expression of CD34 with decreased CD33 and aberrant expression of CD5 in blasts of AML-CK, while AML-TP53 blasts exhibited brighter expression of CD13. Granulocytes in AML-CK exhibited brighter expression of CD5, CD7, CD10 and CD14, with brighter CD3 also seen in AML-TP53. CONCLUSIONS: mutation, including increased expression of T-cell antigens.