Smart nano-assembly from traditional Chinese medicine: Manganese-enhanced polysaccharide platform for orchestrated cancer chemo-immunotherapy

The LUT@POP-FH-Mn synergistically combines natural compounds and metal ions, improving drug delivery and efficacy through integrated chemotherapy, CDT, and immunotherapy. This work provides an innovative model for modernizing traditional Chinese medicine and demonstrates the promise of natural product-based nanomedicine for combined cancer therapy.