FACIAL BIOSTIMULATORS IN AESTHETIC MEDICINE: NEOCOLLAGENESIS MECHANISMS, CLINICAL APPLICATIONS AND REGENERATIVE PERSPECTIVES

Introduction: Facial aging involves cutaneous, adipose, muscular, and bone alterations, with progressive reduction of collagen and loss of skin quality. In this context, biostimulators have stood out for inducing neocollagenesis and dermal remodeling. Objective: To analyze the mechanisms of action, clinical applications, efficacy, safety, and regenerative perspectives of poly-L-lactic acid (PLLA) and calcium hydroxyapatite (CaHA). Methodology: An integrative literature review of descriptive character and qualitative approach, conducted in PubMed/MEDLINE, Scopus, and Virtual Health Library databases, including publications between 2021 and 2026. A total of 687 records were identified, of which 21 studies met the eligibility criteria and composed the final synthesis. Results: The studies demonstrated that PLLA and CaHA promote fibroblastic activation, neocollagenesis, and extracellular matrix remodeling. PLLA showed gradual and prolonged response, while CaHA associated initial structural support with progressive biostimulation. Local and transitory adverse events predominated, although rare complications have been described. Conclusion: PLLA and CaHA are effective and safe alternatives for facial rejuvenation, with complementary characteristics and potential application in regenerative aesthetics. However, the heterogeneity of the studies reinforces the need for standardized clinical research with prolonged follow-up.