Objective To discuss heart rate variability and the change characteristics of morning peak heart rate of diabetes patients.Methods 30 cases of patients with diabetes and 30 cases of patients without diabetes were performed respectively the dynamic ECG monitoring in 24 hours to analyze the heart rate variability time domain indexes and morning peak change of heart rate.Results By the rank and test analysis,between the two groups,the differences of parameters SDNN,SDANN,R-MSSD,PNN50 were statistically significant(P 0.01).By the analysis of variance,for the diabetes group,differences of heart rate of three time the maximum and the minimum were not statistically significant(P 0.05),for the group of patients without diabetes,differences of three time heart rate the maximum and the minimum were statistically significant(P 0.05).By t test,diabetes group and the group of patients without diabetes in the morning rises,three time,only heart rate differences in 6∶00-7∶00 between the minimum value were not statistically significant(P 0.05).Conclusion Due to the damage of cardiac autonomic nerve function of diabetes patients,indicators of heart rate variability reduce,the morning peak heart rate does not change significantly.