Objective To discuss the management of drug quantity and amount in outpatient pharmacy,to improve the level of drug administration. Methods Easy error links of management in drug quantity and amount in outpatient pharmacy of our hospital were analyzed. Effective solutions were put forward. Results The efficiency of pharmacy drug quantity and amount management were improved by decreasing error on computer network system,enhancing normative drug management system,improving the pharmaceutical professional level and operation ability. Conclusion The rationality of computer information system is a fundamental guarantee of accuracy of drug quantity and amount in outpatient pharmacy,and the improvement of drug related system is the premise.