Efficacy of trimetazidine in patients with heart failure with normal left ventricular ejection fraction

AIM To investigate the efficacy of trimetazidine(TMZ) in patients with heart failure with normal left ventricular ejection fraction(HFNEF).METHODS After received routine treatment of 6 weeks,98 patients with HFNEF were divided into control group(n = 50) and observation group(n = 48).The patients were given conventional treatment or TMZ treatment(20 mg,po,tid) in the control group and the observation group,respectively.All patients underwent echocardiography and echocardiographic indices were recorded before and 12 months after the treatment.N-terminal pro-B-type natriuretic peptide(NT-proBNP) and cardiac function(NYHA classification) were examined.RESULTS Both left ventricular end diastolic diameter(LVEDD) and NT-proBNP levels were significantly decreased in the observation group compared with the control group((41.8 ± 2.8) mm vs.(43.7 ± 2.6) mm,P 0.05;(782 ± 238) pg.mL-1vs.(873 ± 252) pg.mL-1,P 0.05 respectively).Compared with the control group,cardiac function in patients treated with TMZ was significantly improved(P 0.05).No significant difference between the two groups was noted in LVEF,though TMZ treatment trended towards enhanced LVEF((68.2 ± 2.8) % vs.(67.0 ± 2.5) %,P 0.05).CONCLUSION TMZ improves the cardiac function of patients with HFNEF and alleviates the symptoms of heart failure.