化学
异氰
催化作用
乌吉反应
组分(热力学)
组合化学
有机化学
热力学
物理
作者
Constantinos G. Neochoritis,Despina Livadiotou,Vassilios G. Tsiaras,Tryfon Zarganes Tzitzikas,Evanthia Samatidou
出处
期刊:Tetrahedron
[Elsevier]
日期:2016-08-01
卷期号:72 (33): 5149-5156
被引量:8
标识
DOI:10.1016/j.tet.2016.07.013
摘要
Isocyanide-based MCRs (IMCRs) involving for the first time the biological and pharmaceutical active indoleacetic acids are studied. In particular, the catalytic behavior of 2-acetyl-indoleacetic acid in the Ugi three-component reaction with TosMIC is emphasized. The reaction was optimized, revealing the catalytic role of aromatic carboxylic acids as well, yielding a small library of a-aminoamides. Full assignment of all 1H and 13C NMR chemical shifts has been unambiguously achieved.
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