Effect of Yinao Jieyu Prescription on cAMP Signaling Pathway in Cortex and Hippocampus of Rats with Depression

Objective: To study expression of brain cydic adenosine monophosphate(cAMP) pathway and intervention by Chinese medicine Yinao Jieyu prescription in depression rat model.Method: Depression model was established by method of Chronic unpredictable mild stress with isolated support,the expression of PDE4(3′,5′-cyclic-nucleotide phosphodiesterase) and cAMP response element binding protein(CREB) was assayed by(PCR),in the rat brain model of depression left frontal cortex,hippocampus of the brain.Result: The hippocampus,prefrontal cortexand PDE4 were significantly higher than the normal group(P0.05,P0.01),CREB expression was significantly lower than normal group(P0.05,P0.01).Chinese side Yinao Jieyu significantly after intervention in the brain regulated the expression of PDE4 and CREB(P0.05,P0.01).Conclusion: Yinao Jieyu prescription can regulate the expression of PDE4 and CREB in rat depression model,which may be related to regulating cAMP pathway.