Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

Sulfonyl hydrazones were synthesized by one-pot reaction using sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap and environmental safe conditions. The optimized reaction afforded nine products with yields higher than 94% and four products with yields between 34% and 83%. Also, this paper reports, for the first time, the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones synthesis, presenting an excellent perspective to the sustainable production of new drug candidates.