[The tissue heterogeneity of mononuclear phagocyte system cells interacting with Yersinia pestis].

The work deals with the determination of the heterogeneity of cells of the mononuclear phagocyte system, localized in different tissues, in their interaction with Y. pestis. The macrophage populations under study have been found to be heterogeneous in their phagocytic activity with respect to Y. pestis. The digestive activity of alveolar macrophages is considerably lower than that of macrophages localized in other tissues. Macrophages obtained from different tissue are heterogeneous also in the intensity of changes in oxygen-dependent metabolic processes during their contacts with Y. pestis. Alveolar macrophages are less active in this respect than peritoneal ones. Alveolar macrophages under study have been shown to have their own characteristic features; for this reason, the data obtained in the study of one of these populations should not be extrapolated to other populations.