Objective: To compare the patency rate of saphenous vein bypass graft by endoscopic vein harvesting(EVH) and traditional open vein harvesting(OVH) in coronary artery bypass grafting(CABG). Methods: 380 coronary heart disease(CHD) cases underwent CABG in our hospital from February 2012 to February 2013 were admitted and divided into EVH group(n=178) and OVH group(n=202) according to the different ways of harvesting great saphenous vein. Coronary artery CT was applied one year after the surgery to observe the patency of saphenous vein bypass graft. Results: No intraoperative adverse events occurred. A total of 376 vein grafts were completed in EVH group. 19 cases lost follow-up and coronary artery CT examination one year after the surgery showed that 21 out of remained 333 grafts occurred vascular restenosis. 458 vein grafts were completed in OVH group. 11 cases lost follow-up and coronary artery CT examination one year after the surgery showed that 26 out of remained 427 grafts occurred vascular restenosis.Statistical analysis demonstrated that no significant differences existed between the two groups(P 0.05). Conclusion: No obvious statistical differences existed in saphenous vein bypass graft patency rate by endoscopic vein harvesting and traditional open vein harvesting in coronary artery bypass grafting.