Intubation application study of different doses of dexmedetomidine given composite target-controlled remifentanil awake in adults

Objective To investigate different doses of dexmedetomidine given composite target- controlled remifentanil in adult awake tracheal intubation. Methods Between March 2011 and March 2013 in our hospital,anesthesia 36 patients were randomly divided into the first group,the second group and the third group,12 cases were included in each group. All patients were given surface anesthesia in the mouth,throat. The intravenous infusion 0. 8 μg / kg of dexmedetomidine was given a loading dose. The first group of patients was given with 0. 25 μg /( k·h) as a maintenance dose. The second group patients was given with 0. 5 μg/( k·h) as a maintenance dose. The third group of patients was given 1. 0 μg /( k·h) as a maintenance dose. Meanwhile target- controlled infusion of remifentanil 4 ng / ml. When BIS values were less than 55.These patients were given endotracheal intubation. Anesthesia condition before( T0),before intubation( T1),intubation 1 min( T2),5min( T3) of MAP,Sp O2,heart rate and changes in BIS after intubation were recorded. The before and after intubation bradycardia,cough,respiratory depression and nausea occurrence were recorded. Results The patients in each group after the first decline in MAP increased. The third group of patients with T2,T3 was compared T0 time point with the same point in time MAP group. The difference was statistically significant( P 0.05). The third group of patients with T1,T2,T3 time Sp O2 decreased significantly compared with T0 time point. The difference was statistically significant( P 0. 05). The increase of each group took the lead after cardiac decline. BIS showed varying degree of reduction. The second group,the third group of patients T2,HR and BIS T3 time points were compared with the same time the first set point,which showed a significant difference( P 0. 05). The incidence of bradycardia and respiratory depression third group of patients was significantly higher than that of the first and second group( P 0. 05). Conclusion 0. 5 μg /( k·h) as a maintenance dose of dexmedetomidine can give composite target- controlled remifentanil awake tracheal intubation in adults. This method showed good anesthetic effect,and can get a stable hemodynamic and low incidence of adverse reactions.