The desalination of fermented broth containing 1,3-propanediol by ion exchange coupling with electrodialysis was studied.Based on the laboratory-scale desalination experiment,the electrodialytical desalination,ion exchange resin,and the coupling process were also investigated.It is shown that the 1,3-PDO loss was 11.41% by electrodialysis.Among the various cationic and anionic resins,LSI296 and LSI010 were chosen to be used at pilot level by comparing pH,conductivity and exchange volume.The efficiency of desalination was improved to 96.2%,and the loss of 1,3-PDO was decreased to 5.88% by ion exchange coupling with electrodialysis.